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Antibody Product Overview
| ELK.No | ES3991 |
| Product name | Nectin 3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | PVRL3; PRR3; Poliovirus receptor-related protein 3; CDw113; Nectin-3; CD113 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 25945 |
| Human Swiss-Prot | Q9NQS3 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Nectin 3 |
| Fields | >>Cell adhesion molecules;>>Adherens junction |
| Gene name | PVRL3 |
| Protein name | Poliovirus receptor-related protein 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 58998 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9JLB9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human PVRL3. AA range:311-360 |
| Specificity | Nectin 3 Polyclonal Antibody detects endogenous levels of Nectin 3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011], |
| Function | function:Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR |
| Subcellular location | Cell membrane ; Single-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane . |
| Expression | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. |
Additional Images
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Western Blot analysis of HeLa cells using Nectin 3 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western blot analysis of lysate from HeLa cells, using PVRL3 Antibody.
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: AO-06-ES3991-100
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