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Antibody Product Overview
| ELK.No | ES4022 |
| Product name | MACC1 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 346389 |
| Human Swiss-Prot | Q6ZN28 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MACC1 |
| Fields | |
| Gene name | MACC1 |
| Protein name | Metastasis-associated in colon cancer protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460 |
| Specificity | MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 97kD |
| Background | MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009], |
| Function | function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors.,tissue specificity:Preferentially expressed in metastasizing tumors., |
| Subcellular location | Cytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors. |
| Expression | Preferentially expressed in metastasizing tumors. |
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: AO-06-ES4022-50
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