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Antibody Product Overview
| ELK.No | ES4033 |
| Product name | BMP-3A rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | BMP3; BMP3A; Bone morphogenetic protein 3; BMP-3; Bone morphogenetic protein 3A; BMP-3A; Osteogenin |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 651 |
| Human Swiss-Prot | P12645 |
| Source | Rabbit |
| Isotype | IgG |
| Target | BMP-3A |
| Fields | >>Cytokine-cytokine receptor interaction |
| Gene name | BMP3 |
| Protein name | Bone morphogenetic protein 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 110075 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BHE5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25667 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P49002 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human BMP3. AA range:421-470 |
| Specificity | BMP-3A Polyclonal Antibody detects endogenous levels of BMP-3A protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 53kD |
| Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016], |
| Function | function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.,induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.,online information:Bone morphogenetic protein 3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in adult and fetal cartilage., |
| Subcellular location | Secreted. |
| Expression | Expressed in adult and fetal cartilage. |
Additional Images
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Western Blot analysis of Jurkat cells using BMP-3A Polyclonal Antibody. Antibody was diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded mouse-muscle, antibody was diluted at 1:100
: AO-06-ES4033-50
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