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Antibody Product Overview
| ELK.No | ES4180 |
| Product name | SDHB rabbit pAb |
| Reactivity | Human;Mouse;Rat;Fish |
| Applications | WB;IHC;IF;ELISA |
| Other name | SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6390 |
| Human Swiss-Prot | P21912 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SDHB |
| Fields | >>Citrate cycle (TCA cycle);>>Oxidative phosphorylation;>>Metabolic pathways;>>Carbon metabolism;>>Thermogenesis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy |
| Gene name | SDHB |
| Protein name | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit mitochondrial |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 67680 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CQA3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 298596 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P21913 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human SDHB. AA range:131-180 |
| Specificity | SDHB Polyclonal Antibody detects endogenous levels of SDHB protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 31kD |
| Background | Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Succinate + ubiquinone = fumarate + ubiquinol.,cofactor:Binds 1 2Fe-2S cluster.,cofactor:Binds 1 3Fe-4S cluster.,cofactor:Binds 1 4Fe-4S cluster.,disease:Defects in SDHB are a cause of Cowden-like syndrome [MIM:612359]. Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus.,disease:Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma [MIM:606864]; also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with inc |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| Expression | Brain,Fibroblast,Liver, |
Additional Images
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Western Blot analysis of HeLa, 293 cells using SDHB Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-muscle, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:100
: AO-06-ES4180-50
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