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Antibody Product Overview
| ELK.No | ES4185 |
| Product name | PRX I rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | PRDX1; PAGA; PAGB; TDPX2; Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5052 |
| Human Swiss-Prot | Q06830 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Prdx1 |
| Fields | >>Peroxisome;>>Amoebiasis |
| Gene name | PRDX1 |
| Protein name | Peroxiredoxin-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18477 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P35700 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 117254 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63716 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human PRDX1. AA range:31-80 |
| Specificity | PRX I Polyclonal Antibody detects endogenous levels of PRX I protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 21kD |
| Background | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011], |
| Function | catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,function:Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).,induction:Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells.,miscellaneous:Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.,miscellaneous:The active site is the redox-active Cys-52 oxidized to Cys-SOH. |
| Subcellular location | Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Expression | Brain,Cajal-Retzius cell,Fetal brain cortex,Urinary bladder, |
Additional Images
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Western Blot analysis of HeLa cells using PRX I Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
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Western blot analysis of lysate from HeLa cells, using PRDX1 Antibody.
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: AO-06-ES4185-50
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