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Antibody Product Overview
| ELK.No | ES4210 |
| Product name | CD223 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | LAG3; FDC; Lymphocyte activation gene 3 protein; LAG-3; Protein FDC; CD223 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3902 |
| Human Swiss-Prot | P18627 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD223 |
| Fields | |
| Gene name | LAG3 |
| Protein name | Lymphocyte activation gene 3 protein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16768 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61790 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 297596 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5BK54 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human LAG3. AA range:91-140 |
| Specificity | CD223 Polyclonal Antibody detects endogenous levels of CD223 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 57kD |
| Background | Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008], |
| Function | function:Involved in lymphocyte activation. Binds to HLA class-II antigens.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:On cell surface of activated NK and T-lymphocytes., |
| Subcellular location | [Lymphocyte activation gene 3 protein]: Cell membrane ; Single-pass type I membrane protein .; [Secreted lymphocyte activation gene 3 protein]: Secreted . Produced following cleavage of the main chain. . |
| Expression | Primarily expressed in activated T-cells and a subset of natural killer (NK) cells. |
Additional Images
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Western Blot analysis of NIH-3T3 cells using CD223 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES4210-100
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