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Antibody Product Overview
| ELK.No | ES4250 |
| Product name | TRPC3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | TRPC3; TRP3; Short transient receptor potential channel 3; TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 7222 |
| Human Swiss-Prot | Q13507 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TRPC3 |
| Fields | >>Axon guidance;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | TRPC3 |
| Protein name | Short transient receptor potential channel 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9QZC1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q9JMI9 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human TRPC3. AA range:411-460 |
| Specificity | TRPC3 Polyclonal Antibody detects endogenous levels of TRPC3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 97kD |
| Background | transient receptor potential cation channel subfamily C member 3(TRPC3) Homo sapiens The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011], |
| Function | function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 5 ANK repeats.,subunit:Interacts with TRPC1. Interacts with ITPR3. Interacts with MX1 and RNF24.,tissue specificity:Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis., |
| Subcellular location | Membrane; Multi-pass membrane protein. |
| Expression | Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis. |
Additional Images
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Western Blot analysis of HeLa cells using TRPC3 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:100
: AO-06-ES4250-100
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