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Antibody Product Overview
| ELK.No | ES4266 |
| Product name | OAS2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | OAS2; 2'-5'-oligoadenylate synthase 2; (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; p69OAS / p71OAS |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4939 |
| Human Swiss-Prot | P29728 |
| Source | Rabbit |
| Isotype | IgG |
| Target | OAS2 |
| Fields | >>NOD-like receptor signaling pathway;>>Hepatitis C;>>Measles;>>Influenza A;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19 |
| Gene name | OAS2 |
| Protein name | 2'-5'-oligoadenylate synthase 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 246728 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | E9Q9A9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 363938 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5MYU0 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2. AA range:61-110 |
| Specificity | OAS2 Polyclonal Antibody detects endogenous levels of OAS2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 82kD |
| Background | 2'-5'-oligoadenylate synthetase 2(OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.,function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.,induction:By interferons.,similarity:Belongs to the 2-5A synthetase family.,subcellular location:Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.,subunit:Homodimer., |
| Subcellular location | Cytoplasm . Cytoplasm, perinuclear region . |
| Expression | Blood,Colon,Testis,Uterus, |
Additional Images
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Western Blot analysis of HeLa cells using OAS2 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-uterus, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-uterus, antibody was diluted at 1:100
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: AO-06-ES4266-100
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