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Antibody Product Overview
| ELK.No | ES4280 |
| Product name | ApoC-III rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | APOC3; Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 345 |
| Human Swiss-Prot | P02656 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ApoC-III |
| Fields | >>PPAR signaling pathway;>>Cholesterol metabolism |
| Gene name | APOC3 |
| Protein name | Apolipoprotein C-III |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P33622 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human APOC3. AA range:46-95 |
| Specificity | ApoC-III Polyclonal Antibody detects endogenous levels of ApoC-III protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 11kD |
| Background | Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).,function:Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.,PTM:O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues.,similarity:Belongs to the apolipoprotein C3 family.,tissue specificity:Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine., |
| Subcellular location | Secreted . |
| Expression | Liver. |
Additional Images
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Western Blot analysis of 293T-UV cells using ApoC-III Polyclonal Antibody. Antibody was diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:100
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: AO-06-ES4280-50
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