Français
English
Antibody Product Overview
| ELK.No | ES4298 |
| Product name | CD89 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | FCAR; CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD89 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2204 |
| Human Swiss-Prot | P24071 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD89 |
| Fields | >>Phagosome;>>Staphylococcus aureus infection |
| Gene name | FCAR |
| Protein name | Immunoglobulin alpha Fc receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human FCAR. AA range:31-80 |
| Specificity | CD89 Polyclonal Antibody detects endogenous levels of CD89 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 32kD |
| Background | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008], |
| Function | alternative products:Additional isoforms seem to exist,function:Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.,tissue specificity:Differentially expressed between blood and mucosal myeloid cells. Monocytes express isoform A.1, isoform A.2 and isoform A.3 while alveolar macrophages express isoform A.1 and isoform A.2; however they express only one isoform at their surfaces., |
| Subcellular location | [Isoform A.1]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.2]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.3]: Cell membrane; Single-pass type I membrane protein.; [Isoform B]: Secreted.; [Isoform B-delta-S2]: Secreted. |
| Expression | Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. |
Additional Images
No image
Western Blot analysis of NIH-3T3 cells using CD89 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
No image
Immunohistochemical analysis of paraffin-embedded human-tonsils, antibody was diluted at 1:100
No image
No image
: AO-06-ES4298-50
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package