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Antibody Product Overview
| ELK.No | ES4308 |
| Product name | Integrin αL rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | ITGAL; CD11A; Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3683 |
| Human Swiss-Prot | P20701 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Integrin αL |
| Fields | >>Rap1 signaling pathway;>>Cell adhesion molecules;>>Neutrophil extracellular trap formation;>>Natural killer cell mediated cytotoxicity;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Malaria;>>Staphylococcus aureus infection;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Rheumatoid arthritis;>>Viral myocarditis |
| Gene name | ITGAL |
| Protein name | Integrin alpha-L |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P24063 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human ITGAL. AA range:171-220 |
| Specificity | Integrin αL Polyclonal Antibody detects endogenous levels of Integrin αL protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 130kD |
| Background | integrin subunit alpha L(ITGAL) Homo sapiens ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.,tissue specificity:Leukocytes., |
| Subcellular location | Cell membrane ; Single-pass type I membrane protein . |
| Expression | Leukocytes. |
Additional Images
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Western Blot analysis of 293 cells using Integrin αL Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES4308-100
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