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Antibody Product Overview
| ELK.No | ES4376 |
| Product name | BMP-15 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | BMP15; GDF9B; Bone morphogenetic protein 15; BMP-15; Growth/differentiation factor 9B; GDF-9B |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9210 |
| Human Swiss-Prot | O95972 |
| Source | Rabbit |
| Isotype | IgG |
| Target | BMP-15 |
| Fields | >>Cytokine-cytokine receptor interaction;>>Ovarian steroidogenesis |
| Gene name | BMP15 |
| Protein name | Bone morphogenetic protein 15 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12155 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9Z0L4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human BMP15. AA range:291-340 |
| Specificity | BMP-15 Polyclonal Antibody detects endogenous levels of BMP-15 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 45kD |
| Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016], |
| Function | disease:Defects in BMP15 are the cause of ovarian dysgenesis 2 (ODG2) [MIM:300510]; also called X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Hypergonadotropic ovarian failure is a heterogeneous disorder that, in the most severe forms, is a result of ovarian dysgenesis (OD) or ovarian defective development. OD accounts for about half of the cases of primary amenorrhea.,function:May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.,miscellaneous:The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked., |
| Subcellular location | Secreted. |
| Expression |
Additional Images
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Western Blot analysis of PC12 cells using BMP-15 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded Human Amygdala. 1, Antibody was diluted at 1:200(4° overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
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Immunohistochemical analysis of paraffin-embedded Human Amygdala. 1, Antibody was diluted at 1:200(4° overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
No image
Immunohistochemical analysis of paraffin-embedded Human Amygdala. 1, Antibody was diluted at 1:200(4° overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
: AO-06-ES4376-50
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