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Troponin I-C (phospho Ser22/S23) rabbit pAb
AO-06-ES4389-100
Antibody Product Overview
| ELK.No | ES4389 |
| Product name | Troponin I-C (phospho Ser22/S23) rabbit pAb |
| Reactivity | Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac troponin I |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | |
| Human Swiss-Prot | |
| Source | Rabbit |
| Isotype | IgG |
| Target | Troponin I-C |
| Fields | |
| Gene name | Tnni3 |
| Protein name | Troponin I cardiac muscle |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | 21954 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | 29248 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P23693 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from mouse TNNI3 around the phosphorylation site of Ser22 and Ser23. AA range:5-54 |
| Specificity | Phospho-Troponin I-C (S22/S23) Polyclonal Antibody detects endogenous levels of Troponin I-C protein only when phosphorylated at S22/S23. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 28kD |
| Background | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: tnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). |
| Function | |
| Subcellular location | |
| Expression |
Additional Images
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Western Blot analysis of SH-SY5Y cells using Phospho-Troponin I-C (S22/S23) Polyclonal Antibody diluted at 1:1000
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using TNNI3 (Phospho-Ser22+Ser23) Antibody
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Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using TNNI3 (Phospho-Ser22+Ser23) Antibody. The picture on the right is blocked with the phospho peptide.
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Western blot analysis of lysates from mouse heart, using TNNI3 (Phospho-Ser22+Ser23) Antibody. The lane on the right is blocked with the phospho peptide.
: AO-06-ES4389-100
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