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Antibody Product Overview
| ELK.No | ES4401 |
| Product name | USP11 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IF;WB;ELISA |
| Other name | USP11; UHX1; Ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8237 |
| Human Swiss-Prot | P51784 |
| Source | Rabbit |
| Isotype | IgG |
| Target | USP11 |
| Fields | |
| Gene name | USP11 |
| Protein name | Ubiquitin carboxyl-terminal hydrolase 11 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 236733 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q99K46 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from the Internal region of human USP11. |
| Specificity | USP11 Polyclonal Antibody detects endogenous levels of USP11 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | IF: 1:50-200 Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,subunit:Interacts with RANBP9/RANBPM., |
| Subcellular location | Nucleus . Cytoplasm . Chromosome . Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726). . |
| Expression | Brain,Fetal brain,Muscle,Retina, |
Additional Images
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Immunofluorescence analysis of human-uterus tissue. 1,USP11 Polyclonal Antibody(red) was diluted at 1:200(4° overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B
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Immunofluorescence analysis of human-lung tissue. 1,USP11 Polyclonal Antibody(red) was diluted at 1:200(4° overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B
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Western Blot analysis of 293 cells using USP11 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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: AO-06-ES4401-100
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