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Antibody Product Overview
| ELK.No | ES4469 |
| Product name | Epac rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | RAPGEF3; CGEF1; EPAC; EPAC1; Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10411 |
| Human Swiss-Prot | O95398 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Epac |
| Fields | >>Rap1 signaling pathway;>>cAMP signaling pathway;>>Phospholipase D signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Leukocyte transendothelial migration;>>Long-term potentiation;>>Serotonergic synapse |
| Gene name | RAPGEF3 |
| Protein name | Rap guanine nucleotide exchange factor 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 223864 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8VCC8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 59326 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9Z1C8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RAPGEF3. AA range:712-761 |
| Specificity | Epac Polyclonal Antibody detects endogenous levels of Epac protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 100kD |
| Background | caution:It is uncertain whether Met-1 or Met-43 is the initiator.,domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney., |
| Function | caution:It is uncertain whether Met-1 or Met-43 is the initiator.,domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney., |
| Subcellular location | Endomembrane system . |
| Expression | Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. |
Additional Images
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Western blot analysis of the lysates from HeLa cells using RAPGEF3 antibody.
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: AO-06-ES4469-50
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