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Antibody Product Overview
| ELK.No | ES4476 |
| Product name | Vav3 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | VAV3; Guanine nucleotide exchange factor VAV3; VAV-3 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10451 |
| Human Swiss-Prot | Q9UKW4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Vav3 |
| Fields | >>Rap1 signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Focal adhesion;>>Natural killer cell mediated cytotoxicity;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Yersinia infection;>>Proteoglycans in cancer;>>Lipid and atherosclerosis |
| Gene name | VAV3 |
| Protein name | Guanine nucleotide exchange factor VAV3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 57257 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9R0C8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VAV3. AA range:139-188 |
| Specificity | Vav3 Polyclonal Antibody detects endogenous levels of Vav3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 98kD |
| Background | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008], |
| Function | function:Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with the PH domain of APS., |
| Subcellular location | intracellular,cytosol,plasma membrane,extracellular exosome, |
| Expression | Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. |
Additional Images
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Western Blot analysis of 293T-UV cells using Vav3 Polyclonal Antibody diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western blot analysis of the lysates from HepG2 cells using VAV3 antibody.
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: AO-06-ES4476-50
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