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Antibody Product Overview
| ELK.No | ES4516 |
| Product name | Cdc42EP3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CDC42EP3; BORG2; CEP3; Cdc42 effector protein 3; Binder of Rho GTPases 2; MSE55-related Cdc42-binding protein |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10602 |
| Human Swiss-Prot | Q9UKI2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Cdc42EP3 |
| Fields | |
| Gene name | CDC42EP3 |
| Protein name | Cdc42 effector protein 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 260409 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CQC5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Cdc42EP3. |
| Specificity | Cdc42EP3 Polyclonal Antibody detects endogenous levels of Cdc42EP3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 26kD |
| Background | This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012], |
| Function | function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart and weakly in the brain., |
| Subcellular location | Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton . |
| Expression | Highly expressed in the heart and weakly in the brain. |
Additional Images
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Western Blot analysis of K562 cells using Cdc42EP3 Polyclonal Antibody
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: AO-06-ES4516-50
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