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Antibody Product Overview
| ELK.No | ES4522 |
| Product name | Hexim1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | HEXIM1; CLP1; EDG1; HIS1; MAQ1; Protein HEXIM1; Cardiac lineage protein 1; Estrogen down-regulated gene 1 protein; Hexamethylene bis-acetamide-inducible protein 1; Menage a quatre protein 1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10614 |
| Human Swiss-Prot | O94992 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Hexim1 |
| Fields | |
| Gene name | HEXIM1 |
| Protein name | Protein HEXIM1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 192231 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8R409 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 498008 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5M9G1 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230 |
| Specificity | Hexim1 Polyclonal Antibody detects endogenous levels of Hexim1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 40kD |
| Background | Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008], |
| Function | domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.,miscellaneous:Inhibits Tat activity which is required for HIV-1 transcription.,similarity:Belongs to the HEXIM family.,subcellular location:Binds alpha-importin and is mostly nuclear.,subunit:Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, H |
| Subcellular location | Nucleus . Cytoplasm . Binds alpha-importin and is mostly nuclear (PubMed:16362050). |
| Expression | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
Additional Images
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Western Blot analysis of RAT-HEART cells using Hexim1 Polyclonal Antibody diluted at 1:2000
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Immunofluorescence analysis of HeLa cells, using HEXIM1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from NIH/3T3 cells, using HEXIM1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HeLa cells using HEXIM1 antibody.
: AO-06-ES4522-100
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