Français
English
Antibody Product Overview
| ELK.No | ES4562 |
| Product name | PDE10A rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB;ELISA;IHC |
| Other name | PDE10A; cAMP and cAMP-inhibited cGMP 3'; 5'-cyclic phosphodiesterase 10A |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10846 |
| Human Swiss-Prot | Q9Y233 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PDE10A |
| Fields | >>Purine metabolism;>>Metabolic pathways;>>cAMP signaling pathway;>>Morphine addiction |
| Gene name | PDE10A |
| Protein name | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8CA95 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 63885 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9QYJ6 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PDE10A. AA range:21-70 |
| Specificity | PDE10A Polyclonal Antibody detects endogenous levels of PDE10A protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 75kD |
| Background | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011], |
| Function | alternative products:Isoforms differ in their N-terminal region,catalytic activity:Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 1 zinc ion.,domain:Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.,domain:The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity.,enzyme regulation:Inhibited by dipyridamole and moderately by IBMX. cAMP acts as an allosteric activator.,function:Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient w |
| Subcellular location | Cytoplasm, cytosol . |
| Expression | Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum. |
Additional Images
No image
Western Blot analysis of A549 cells using PDE10A Polyclonal Antibody
No image
Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
No image
No image
: AO-06-ES4562-100
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package