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Cdc37 (phospho Ser13) rabbit pAb
AO-06-ES4604-50
Antibody Product Overview
| ELK.No | ES4604 |
| Product name | Cdc37 (phospho Ser13) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | CDC37; CDC37A; Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 11140 |
| Human Swiss-Prot | Q16543 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Cdc37 |
| Fields | >>PI3K-Akt signaling pathway |
| Gene name | CDC37 |
| Protein name | Hsp90 co-chaperone Cdc37 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12539 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61081 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 114562 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63692 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDC37 around the phosphorylation site of Ser13. AA range:1-50 |
| Specificity | Phospho-Cdc37 (S13) Polyclonal Antibody detects endogenous levels of Cdc37 protein only when phosphorylated at S13. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 44kD |
| Background | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008], |
| Function | function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1., |
| Subcellular location | Cytoplasm . |
| Expression | Lymph,Placenta, |
Additional Images
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Western Blot analysis of 3T3 cells using Phospho-Cdc37 (S13) Polyclonal Antibody
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Immunohistochemical analysis of paraffin-embedded Human lung cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
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Immunohistochemistry analysis of paraffin-embedded human placenta, using CDC37 (Phospho-Ser13) Antibody. The picture on the right is blocked with the phospho peptide.
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Western blot analysis of lysates from HUVEC cells, using CDC37 (Phospho-Ser13) Antibody. The lane on the right is blocked with the phospho peptide.
: AO-06-ES4604-50
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