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Antibody Product Overview
| ELK.No | ES4630 |
| Product name | mAChR M1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CHRM1; Muscarinic acetylcholine receptor M1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1128 |
| Human Swiss-Prot | P11229 |
| Source | Rabbit |
| Isotype | IgG |
| Target | mAChR M1 |
| Fields | >>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>Cholinergic synapse;>>Regulation of actin cytoskeleton;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | CHRM1 |
| Protein name | Muscarinic acetylcholine receptor M1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12669 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P12657 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25229 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P08482 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHRM1. AA range:295-344 |
| Specificity | mAChR M1 Polyclonal Antibody detects endogenous levels of mAChR M1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 51kD |
| Background | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008], |
| Function | function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with GPRASP2., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Expression | Amygdala,Brain, |
Additional Images
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Western Blot analysis of HepG2 cells using mAChR M1 Polyclonal Antibody
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Western blot analysis of lysates from HepG2 cells, using CHRM1 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES4630-100
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