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Antibody Product Overview
| ELK.No | ES4690 |
| Product name | TPH2 rabbit pAb |
| Reactivity | Human;Mouse;Rat;Monkey |
| Applications | WB;ELISA |
| Other name | TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 121278 |
| Human Swiss-Prot | Q8IWU9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TPH2 |
| Fields | >>Tryptophan metabolism;>>Folate biosynthesis;>>Metabolic pathways;>>Serotonergic synapse |
| Gene name | TPH2 |
| Protein name | Tryptophan 5-hydroxylase 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 216343 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8CGV2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 317675 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q8CGU9 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TPH2. AA range:4-53 |
| Specificity | TPH2 Polyclonal Antibody detects endogenous levels of TPH2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 56kD |
| Background | This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016], |
| Function | catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,tissue specificity:Brain specific., |
| Subcellular location | cytosol,neuron projection, |
| Expression | Brain specific. |
Additional Images
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Western Blot analysis of HeLa cells using TPH2 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western blot analysis of the lysates from HUVECcells using TPH2 antibody.
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: AO-06-ES4690-100
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