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Antibody Product Overview
| ELK.No | ES4700 |
| Product name | Relaxin Receptor 2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC |
| Other name | RXFP2; GPR106; GREAT; LGR8; Relaxin receptor 2; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 122042 |
| Human Swiss-Prot | Q8WXD0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Relaxin Receptor 2 |
| Fields | >>Neuroactive ligand-receptor interaction;>>Relaxin signaling pathway |
| Gene name | RXFP2 |
| Protein name | Relaxin receptor 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 140498 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91ZZ5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RXFP2. AA range:113-162 |
| Specificity | Relaxin Receptor 2 Polyclonal Antibody detects endogenous levels of Relaxin Receptor 2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 86kD |
| Background | This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009], |
| Function | caution:It is uncertain whether Met-1 or Met-18 is the initiator.,disease:Defects in RXFP2 are a cause of cryptorchidism [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.,function:Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow. |
Additional Images
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Western Blot analysis of Jurkat cells using Relaxin Receptor 2 Polyclonal Antibody
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Western blot analysis of lysates from Jurkat cells, using RXFP2 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HUVECcells using RXFP2 antibody.
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
: AO-06-ES4700-50
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