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Antibody Product Overview
| ELK.No | ES4723 |
| Product name | CB1 rabbit pAb |
| Reactivity | Human;Mouse;Rat;Monkey |
| Applications | WB;IHC;IF;ELISA |
| Other name | CNR1; CNR; Cannabinoid receptor 1; CB-R; CB1; CANN6 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1268 |
| Human Swiss-Prot | P21554 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CB1 |
| Fields | >>Rap1 signaling pathway;>>Neuroactive ligand-receptor interaction;>>Thermogenesis;>>Retrograde endocannabinoid signaling |
| Gene name | CNR1 |
| Protein name | Cannabinoid receptor 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12801 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P47746 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25248 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P20272 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CNR1. AA range:151-200 |
| Specificity | CB1 Polyclonal Antibody detects endogenous levels of CB1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 53kD |
| Background | This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009], |
| Function | function:Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts (via C-terminus) with CNRIP1.,tissue specificity:Widely expressed., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Membrane raft . Mitochondrion outer membrane . Cell projection, axon . Cell junction, synapse, presynapse . Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity). . |
| Expression | Widely expressed, with highest levels in fetal and adult brain. Expression levels of isoform 2 and isoform 3 are much lower than those of isoform 1. |
Additional Images
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Western Blot analysis of HT-29 cells using CB1 Polyclonal Antibody
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Immunofluorescence analysis of LOVO cells, using CNR1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CNR1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HT-29 and COS7 cells, using CNR1 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES4723-100
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