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Antibody Product Overview
| ELK.No | ES4754 |
| Product name | ACTR-IC rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | ACVR1C; ALK7; Activin receptor type-1C; Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 130399 |
| Human Swiss-Prot | Q8NER5 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ACTR-IC |
| Fields | >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells |
| Gene name | ACVR1C |
| Protein name | Activin receptor type-1C |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 269275 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8K348 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 245921 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P70539 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ACTR-1C. AA range:201-250 |
| Specificity | ACTR-IC Polyclonal Antibody detects endogenous levels of ACTR-IC protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 55kD |
| Observed band (KD) | |
| Background | ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008], |
| Function | catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds the type 2 receptor protein ACVR2A.,tissue specificity:Present in pancreas, heart, colon, small intestine, ovary and |
| Subcellular location | Membrane ; Single-pass type I membrane protein . |
| Expression | Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. |
Additional Images
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Immunofluorescence analysis of COS7 cells, using ACTR-1C Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ACTR-1C Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES4754-50
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