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Antibody Product Overview
| ELK.No | ES4764 |
| Product name | Glycerate Kinase rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | GLYCTK; HBEBP4; LP5910; Glycerate kinase; HBeAg-binding protein 4 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 132158 |
| Human Swiss-Prot | Q8IVS8 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Glycerate Kinase |
| Fields | >>Pentose phosphate pathway;>>Glycine, serine and threonine metabolism;>>Glycerolipid metabolism;>>Glyoxylate and dicarboxylate metabolism;>>Metabolic pathways;>>Carbon metabolism |
| Gene name | GLYCTK |
| Protein name | Glycerate kinase |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 235582 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8QZY2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 684314 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q0VGK3 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GLCTK. AA range:101-150 |
| Specificity | Glycerate Kinase Polyclonal Antibody detects endogenous levels of Glycerate Kinase protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009], |
| Function | catalytic activity:ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate.,disease:Defects in GLYCTK are the cause of D-glyceric acidemia [MIM:220120]. It is characterized by nonketotic hyperglycinemia with the excretion of D-glyceric acid in the urine and the presence of this substance in the serum.,similarity:Belongs to the glycerate kinase type-2 family.,tissue specificity:Widely expressed., |
| Subcellular location | [Isoform 1]: Cytoplasm .; [Isoform 2]: Cytoplasm. Mitochondrion . |
| Expression | Widely expressed. |
Additional Images
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Immunofluorescence analysis of A549 cells, using GLCTK Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GLCTK Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from NIH/3T3 cells, using GLCTK Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HUVECcells using GLCTK antibody.
: AO-06-ES4764-100
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