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Antibody Product Overview
| ELK.No | ES4855 |
| Product name | Csk rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1445 |
| Human Swiss-Prot | P41240 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Csk |
| Fields | >>Epithelial cell signaling in Helicobacter pylori infection |
| Gene name | CSK |
| Protein name | Tyrosine-protein kinase CSK |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12988 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P41241 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 315707 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P32577 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from N-ternal human CSK. AA range:31-80 |
| Specificity | Csk Polyclonal Antibody detects endogenous levels of Csk protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 55kD |
| Background | catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages., |
| Function | catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages., |
| Subcellular location | Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. . |
| Expression | Expressed in lung and macrophages. |
Additional Images
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Western Blot analysis of Jurkat cells using Csk Polyclonal Antibody
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Immunofluorescence analysis of A549 cells, using CSK Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from Jurkat cells, using CSK Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES4855-50
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