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Antibody Product Overview
| ELK.No | ES4859 |
| Product name | Casein Kinase Iε rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC;IF;ELISA |
| Other name | CSNK1E; Casein kinase I isoform epsilon; CKI-epsilon; CKIe |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1454 |
| Human Swiss-Prot | P49674 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Casein Kinase Iε |
| Fields | >>FoxO signaling pathway;>>Wnt signaling pathway;>>Hedgehog signaling pathway;>>Hippo signaling pathway;>>Hippo signaling pathway - multiple species;>>Circadian rhythm;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | CSNK1E |
| Protein name | Casein kinase I isoform epsilon |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 27373 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9JMK2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CKI-epsilon. AA range:276-325 |
| Specificity | Casein Kinase Iε Polyclonal Antibody detects endogenous levels of Casein Kinase Iε protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 47kD |
| Background | casein kinase 1 epsilon(CSNK1E) Homo sapiens The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014], |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.,induction:Down-regulated during granulocytic differentiation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Component of the circadian core oscillator, which includes the CRY pro |
| Subcellular location | Cytoplasm . Nucleus . |
| Expression | Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes. |
Additional Images
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Western Blot analysis of LOVO cells using Casein Kinase Iε Polyclonal Antibody
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Immunofluorescence analysis of HeLa cells, using CKI-epsilon Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using CKI-epsilon Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from LOVO cells, using CKI-epsilon Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES4859-100
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