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Antibody Product Overview
| ELK.No | ES4871 |
| Product name | Cystatin SN rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | CST1; Cystatin-SN; Cystain-SA-I; Cystatin-1; Salivary cystatin-SA-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1469 |
| Human Swiss-Prot | P01037 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Cystatin SN |
| Fields | >>Salivary secretion |
| Gene name | CST1 |
| Protein name | Cystatin-SN |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CST1. AA range:31-80 |
| Specificity | Cystatin SN Polyclonal Antibody detects endogenous levels of Cystatin SN protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 16kD |
| Observed band (KD) | |
| Background | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008], |
| Function | function:Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.,similarity:Belongs to the cystatin family.,tissue specificity:Found in saliva, tears, urine and seminal fluid., |
| Subcellular location | Secreted . |
| Expression | Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. |
Additional Images
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Western Blot analysis of Jurkat cells using Cystatin SN Polyclonal Antibody
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Immunofluorescence analysis of MCF7 cells, using CST1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CST1 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES4871-50
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