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Antibody Product Overview
| ELK.No | ES4883 |
| Product name | CtBP1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | CTBP1; CTBP; C-terminal-binding protein 1; CtBP1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1487 |
| Human Swiss-Prot | Q13363 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CtBP1 |
| Fields | >>Wnt signaling pathway;>>Notch signaling pathway;>>Pathways in cancer;>>Chronic myeloid leukemia |
| Gene name | CTBP1 |
| Protein name | C-terminal-binding protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13016 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O88712 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29382 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9Z2F5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CtBP1. AA range:388-437 |
| Specificity | CtBP1 Polyclonal Antibody detects endogenous levels of CtBP1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 48kD |
| Background | This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008], |
| Function | cofactor:NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change.,function:Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co-repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity.,PTM:ADP-ribosylated; when cells are exposed to brefeldin-A (BFA).,PTM:Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.,PTM:The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Interacts with the C-terminus of adenovirus E1A protein, ELK3 and CTIP via their consensus motif P-X-[DNS]-L-[STVA]. Can form homodime |
| Subcellular location | Cytoplasm . Nucleus . |
| Expression | Expressed in germinal center B-cells. |
Additional Images
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Western Blot analysis of Jurkat cells using CtBP1 Polyclonal Antibody
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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CtBP1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from Jurkat cells, using CtBP1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
: AO-06-ES4883-50
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