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Antibody Product Overview
| ELK.No | ES5003 |
| Product name | ADAMTS-19 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | ADAMTS19; A disintegrin and metalloproteinase with thrombospondin motifs 19; ADAM-TS 19; ADAM-TS19; ADAMTS-19 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 171019 |
| Human Swiss-Prot | Q8TE59 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ADAMTS-19 |
| Fields | |
| Gene name | ADAMTS19 |
| Protein name | A disintegrin and metalloproteinase with thrombospondin motifs 19 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 240322 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P59509 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADAMTS19. AA range:251-300 |
| Specificity | ADAMTS-19 Polyclonal Antibody detects endogenous levels of ADAMTS-19 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 140kD |
| Background | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008], |
| Function | cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library., |
| Subcellular location | Secreted, extracellular space, extracellular matrix . |
| Expression | Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library. |
Additional Images
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Western Blot analysis of 293 cells using ADAMTS-19 Polyclonal Antibody
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Western blot analysis of the lysates from RAW264.7cells using ADAMTS19 antibody.
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: AO-06-ES5003-50
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