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Dynamin I (phospho Ser778) rabbit pAb
AO-06-ES5009-50
Antibody Product Overview
| ELK.No | ES5009 |
| Product name | Dynamin I (phospho Ser778) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | DNM1; DNM; Dynamin-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1759 |
| Human Swiss-Prot | Q05193 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Dynamin I |
| Fields | >>Phospholipase D signaling pathway;>>Endocytosis;>>Synaptic vesicle cycle;>>Endocrine and other factor-regulated calcium reabsorption;>>Bacterial invasion of epithelial cells |
| Gene name | DNM1 |
| Protein name | Dynamin-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13429 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P39053 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 140694 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P21575 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DYN1 around the phosphorylation site of Ser778. AA range:751-800 |
| Specificity | Phospho-Dynamin I (S778) Polyclonal Antibody detects endogenous levels of Dynamin I protein only when phosphorylated at S778. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 100kD |
| Background | dynamin 1(DNM1) Homo sapiens This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,similarity:Contains 1 PH domain.,subcellular location:Microtubule-associated.,subunit:Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated. |
| Expression | Brain,Platelet,PNS, |
Additional Images
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Western Blot analysis of Mouse-Brain cells using Phospho-Dynamin I (S778) Polyclonal Antibody
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Western blot analysis of DYN1 (Phospho-Ser778) Antibody. The lane on the right is blocked with the DYN1 (Phospho-Ser778) peptide.
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: AO-06-ES5009-50
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