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Antibody Product Overview
| ELK.No | ES5052 |
| Product name | CDHF10 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | CELSR2; CDHF10; EGFL2; KIAA0279; MEGF3; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; Epidermal growth factor-like protein 2; EGF-like protein 2; Flamingo homolog 3; Multiple epidermal growth factor-like domains |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1952 |
| Human Swiss-Prot | Q9HCU4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CDHF10 |
| Fields | |
| Gene name | CELSR2 |
| Protein name | Cadherin EGF LAG seven-pass G-type receptor 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9R0M0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q9QYP2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CELSR2. AA range:2781-2830 |
| Specificity | CDHF10 Polyclonal Antibody detects endogenous levels of CDHF10 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 317kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008], |
| Function | function:Receptor that may have an important role in cell/cell signaling during nervous system formation.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 laminin EGF-like domain.,similarity:Contains 2 laminin G-like domains.,similarity:Contains 7 EGF-like domains.,similarity:Contains 9 cadherin domains.,tissue specificity:Highest expression in brain and testis., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Highest expression in brain and testis. |
Additional Images
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Immunofluorescence analysis of COS7 cells, using CELSR2 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CELSR2 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES5052-50
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