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Cleaved-Thrombin R (S42) rabbit pAb
AO-06-ES5185-100
Antibody Product Overview
| ELK.No | ES5185 |
| Product name | Cleaved-Thrombin R (S42) rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | F2R; CF2R; PAR1; TR; Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2149 |
| Human Swiss-Prot | P25116 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Thrombin R |
| Fields | >>Rap1 signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>Complement and coagulation cascades;>>Platelet activation;>>Regulation of actin cytoskeleton;>>Pathogenic Escherichia coli infection;>>Pathways in cancer |
| Gene name | F2R |
| Protein name | Proteinase-activated receptor 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P30558 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PAR1. AA range:23-72 |
| Specificity | Cleaved-Thrombin R (S42) Polyclonal Antibody detects endogenous levels of fragment of activated Thrombin R protein resulting from cleavage adjacent to S42. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 46kD |
| Background | Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015], |
| Function | function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Platelets and vascular endothelial cells. |
Additional Images
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Western Blot analysis of Jurkat cells using Cleaved-Thrombin R (S42) Polyclonal Antibody
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Western blot analysis of lysates from Jurkat cells, using PAR1 (Cleaved-Ser42) Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES5185-100
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