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Antibody Product Overview
| ELK.No | ES5192 |
| Product name | Factor XIII B rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | F13B; Coagulation factor XIII B chain; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2165 |
| Human Swiss-Prot | P05160 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Factor XIII B |
| Fields | >>Complement and coagulation cascades;>>Coronavirus disease - COVID-19 |
| Gene name | F13B |
| Protein name | Coagulation factor XIII B chain |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q07968 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human F13B. AA range:61-110 |
| Specificity | Factor XIII B Polyclonal Antibody detects endogenous levels of Factor XIII B protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 80kD |
| Background | This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classi |
| Function | disease:Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.,function:The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.,online information:Factor XIII entry,online information:The Singapore human mutation and polymorphism database,similarity:Contains 10 Sushi (CCP/SCR) domains.,subunit:Tetramer of two A chains and two B chains., |
| Subcellular location | Secreted . |
| Expression | Heart,Liver,Plasma, |
Additional Images
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Western Blot analysis of COLO cells using Factor XIII B Polyclonal Antibody diluted at 1:1000
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Immunofluorescence analysis of HUVEC cells, using F13B Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human heart tissue, using F13B Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES5192-100
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