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Antibody Product Overview
| ELK.No | ES5261 |
| Product name | KPI-2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | LMTK2; AATYK2; BREK; KIAA1079; KPI2; LMR2; Serine/threonine-protein kinase LMTK2; Apoptosis-associated tyrosine kinase 2; Brain-enriched kinase; hBREK; CDK5/p35-regulated kinase; CPRK; Kinase/phosphatase/inhibitor 2; Lemur tyrosine kinase 2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 22853 |
| Human Swiss-Prot | Q8IWU2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | KPI-2 |
| Fields | |
| Gene name | LMTK2 |
| Protein name | Serine/threonine-protein kinase LMTK2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q3TYD6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LMTK2. AA range:651-700 |
| Specificity | KPI-2 Polyclonal Antibody detects endogenous levels of KPI-2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 164kD |
| Background | The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009], |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates PPP1C, phosphorylase b and CFTR.,online information:LMTK2 entry,PTM:Autophosphorylated. Phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1C and inhibitor-2.,tissue specificity:Mainly expressed in skeletal muscle, and weakly in brain and pancreas., |
| Subcellular location | Membrane ; Multi-pass membrane protein . |
| Expression | Mainly expressed in skeletal muscle, and weakly in brain and pancreas. |
Additional Images
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Western Blot analysis of LOVO cells using KPI-2 Polyclonal Antibody
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Immunofluorescence analysis of HepG2 cells, using LMTK2 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using LMTK2 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from LOVO cells, using LMTK2 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES5261-50
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