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Rabphilin-3A (phospho Ser237) rabbit pAb
AO-06-ES5269-50
Antibody Product Overview
| ELK.No | ES5269 |
| Product name | Rabphilin-3A (phospho Ser237) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | RPH3A; KIAA0985; Rabphilin-3A; Exophilin-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 22895 |
| Human Swiss-Prot | Q9Y2J0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Rabphilin 3A |
| Fields | |
| Gene name | RPH3A |
| Protein name | Rabphilin-3A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 19894 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P47708 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 171039 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P47709 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Rabphilin 3A around the phosphorylation site of Ser237. AA range:203-252 |
| Specificity | Phospho-Rabphilin-3A (S237) Polyclonal Antibody detects endogenous levels of Rabphilin-3A protein only when phosphorylated at S237. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 75kD |
| Background | Exocytosis of neurotransmitters and hormones is fundamental to synaptic neurotransmission and cell-cell communication. RAB3A (MIM 179390) is a small G protein that is thought to act at late stages of exocytosis, and RPH3A is a RAB3A effector (Lin et al., 2007 [PubMed 17149709]).[supplied by OMIM, Jul 2008], |
| Function | function:Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,similarity:Contains 2 C2 domains., |
| Subcellular location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic cell membrane . Membrane ; Peripheral membrane protein . |
| Expression | Brain,Lung, |
Additional Images
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Rabphilin 3A (Phospho-Ser237) Antibody
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Immunofluorescence analysis of HeLa cells, using Rabphilin 3A (Phospho-Ser237) Antibody. The picture on the right is blocked with the phospho peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain, using Rabphilin 3A (Phospho-Ser237) Antibody. The picture on the right is blocked with the phospho peptide.
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Western blot analysis of lysates from RAW264.7 cells treated with Calyculin 100nM 15', using Rabphilin 3A (Phospho-Ser237) Antibody. The lane on the right is blocked with the phospho peptide.
: AO-06-ES5269-50
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