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Fos B (phospho Ser27) rabbit pAb
AO-06-ES5355-50
Antibody Product Overview
| ELK.No | ES5355 |
| Product name | Fos B (phospho Ser27) rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC;IF;ELISA |
| Other name | FOSB; G0S3; Protein fosB; G0/G1 switch regulatory protein 3 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2354 |
| Human Swiss-Prot | P53539 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Fos B |
| Fields | >>Osteoclast differentiation;>>IL-17 signaling pathway;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism |
| Gene name | FOSB |
| Protein name | Protein fosB |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14282 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P13346 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FosB around the phosphorylation site of Ser27. AA range:12-61 |
| Specificity | Phospho-Fos B (S27) Polyclonal Antibody detects endogenous levels of Fos B protein only when phosphorylated at S27. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 35kD |
| Background | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | function:FosB interacts with Jun proteins enhancing their DNA binding activity.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Fos subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer., |
| Subcellular location | Nucleus . |
| Expression | [Isoform 11]: Expressed in the nucleus accumbens of the striatum (at protein level). |
Additional Images
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Immunofluorescence analysis of HUVEC cells treated with EGF 200nM 5', using FosB (Phospho-Ser27) Antibody. The picture on the right is blocked with the phospho peptide.
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Western blot analysis of FosB (Phospho-Ser27) Antibody. The lane on the right is blocked with the FosB (Phospho-Ser27) peptide.
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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