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Antibody Product Overview
| ELK.No | ES5381 |
| Product name | IL-17Rα rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | IL17RA; IL17R; Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD antigen CD217 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 23765 |
| Human Swiss-Prot | Q96F46 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IL-17Rα |
| Fields | >>Cytokine-cytokine receptor interaction;>>IL-17 signaling pathway;>>Alcoholic liver disease |
| Gene name | IL17RA |
| Protein name | Interleukin-17 receptor A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16172 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60943 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IL17RA. AA range:141-190 |
| Specificity | IL-17Rα Polyclonal Antibody detects endogenous levels of IL-17Rα protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 90kD |
| Background | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014], |
| Function | function:Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.,PTM:Glycosylated.,tissue specificity:Widely expressed., |
| Subcellular location | [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted . |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of the lysates from HeLa cells using IL17RA antibody.
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: AO-06-ES5381-50
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