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Gab 1 (phospho Tyr659) rabbit pAb
AO-06-ES5422-50
Antibody Product Overview
| ELK.No | ES5422 |
| Product name | Gab 1 (phospho Tyr659) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2549 |
| Human Swiss-Prot | Q13480 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Gab 1 |
| Fields | >>EGFR tyrosine kinase inhibitor resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Phospholipase D signaling pathway;>>Neurotrophin signaling pathway;>>Bacterial invasion of epithelial cells;>>Proteoglycans in cancer;>>Renal cell carcinoma;>>Hepatocellular carcinoma;>>Gastric cancer |
| Gene name | GAB1 |
| Protein name | GRB2-associated-binding protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14388 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9QYY0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GAB1 around the phosphorylation site of Tyr659. AA range:644-674 |
| Specificity | Phospho-Gab 1 (Y659) Polyclonal Antibody detects endogenous levels of Gab 1 protein only when phosphorylated at Y659. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 76kD |
| Background | GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008], |
| Function | function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2., |
| Subcellular location | cytosol, |
| Expression | Testis,Whole embryo, |
Additional Images
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Western Blot analysis of 3T3 cells using Phospho-Gab 1 (Y659) Polyclonal Antibody
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using GAB1 (Phospho-Tyr659) Antibody
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Immunofluorescence analysis of HepG2 cell, using GAB1 (Phospho-Tyr659) Antibody. The lane on the right is blocked with the GAB1 (Phospho-Tyr659) peptide.
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Immunohistochemistry analysis of paraffin-embedded human breast cancer, using GAB1 (Phospho-Tyr659) Antibody. The picture on the right is blocked with the GAB1 (Phospho-Tyr659) peptide.
: AO-06-ES5422-50
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