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Antibody Product Overview
| ELK.No | ES5448 |
| Product name | NKp30 rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB;ELISA |
| Other name | NCR3; 1C7; LY117; Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD antigen CD337 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 259197 |
| Human Swiss-Prot | O14931 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NKp30 |
| Fields | >>Natural killer cell mediated cytotoxicity |
| Gene name | NCR3 |
| Protein name | Natural cytotoxicity triggering receptor 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q8CFD9 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NCR3. AA range:104-153 |
| Specificity | NKp30 Polyclonal Antibody detects endogenous levels of NKp30 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010], |
| Function | function:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.,polymorphism:A genetic variation in NCR3 is associated with mild malaria suceptibility [MIM:609148].,similarity:Belongs to the natural cytotoxicity receptor (NCR) family.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subunit:Interacts with CD3Z.,tissue specificity:Selectively expressed by all resting and activated NK cells and weakly expressed in spleen., |
| Subcellular location | Cell membrane ; Single-pass type I membrane protein . |
| Expression | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. |
Additional Images
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Western blot analysis of lysates from A549 cells, using NCR3 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from K562 cells using NCR3 antibody.
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: AO-06-ES5448-50
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