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Antibody Product Overview
| ELK.No | ES5567 |
| Product name | Gα i-3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | GNAI3; Guanine nucleotide-binding protein G(k) subunit alpha; G(i) alpha-3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2773 |
| Human Swiss-Prot | P08754 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GNAI3 |
| Fields | >>Rap1 signaling pathway;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Sphingolipid signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Axon guidance;>>Apelin signaling pathway;>>Gap junction;>>Platelet activation;>>Leukocyte transendothelial migration;>>Circadian entrainment;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>GABAergic synapse;>>Dopaminergic synapse;>>Long-term depression;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Melanogenesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Cushing syndrome;>>Growth hormone synthesis, secretion and action;>>Gastric acid secretion;>>Parkinson disease;>>Cocaine addiction;>>Morphine addiction;>>Alcoholism;>>Pertussis;>>Chagas disease;>>Toxoplasmosis;>>Human cytomegalovirus infectio |
| Gene name | GNAI3 |
| Protein name | Guanine nucleotide-binding protein G(k) subunit alpha |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14679 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9DC51 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25643 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P08753 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GNAI3. AA range:31-80 |
| Specificity | Gα i-3 Polyclonal Antibody detects endogenous levels of Gα i-3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 41kD |
| Background | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012], |
| Function | function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1., |
| Subcellular location | Cytoplasm . Cell membrane ; Lipid-anchor . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. . |
| Expression | Liver, |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES5567-100
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