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Antibody Product Overview
| ELK.No | ES5617 |
| Product name | GPR40 rabbit pAb |
| Reactivity | Human;Monkey |
| Applications | WB;IF;ELISA |
| Other name | FFAR1; GPR40; Free fatty acid receptor 1; G-protein coupled receptor 40 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2864 |
| Human Swiss-Prot | O14842 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GPR40 |
| Fields | >>Insulin secretion |
| Gene name | FFAR1 |
| Protein name | Free fatty acid receptor 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q76JU9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FFAR1. AA range:185-234 |
| Specificity | GPR40 Polyclonal Antibody detects endogenous levels of GPR40 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 26kD |
| Background | This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009], |
| Function | function:Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly in pancreatic beta cells., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . |
| Expression | Detected in brain and pancreas. Detected in pancreatic beta cells. |
Additional Images
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Western Blot analysis of COS7 cells using GPR40 Polyclonal Antibody diluted at 1:500
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Western Blot analysis of COS-7 cells using GPR40 Polyclonal Antibody diluted at 1:500
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Western blot analysis of Mouse-kidney lysis using GPR40 antibody. Antibody was diluted at 1:500
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Immunofluorescence analysis of LOVO cells, using FFAR1 Antibody. The picture on the right is blocked with the synthesized peptide.
: AO-06-ES5617-100
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