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Antibody Product Overview
| ELK.No | ES5624 |
| Product name | GRK 6 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | GRK6; GPRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2870 |
| Human Swiss-Prot | P43250 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GRK 6 |
| Fields | >>Chemokine signaling pathway;>>Endocytosis;>>Morphine addiction |
| Gene name | GRK6 |
| Protein name | G protein-coupled receptor kinase 6 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 26385 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O70293 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P97711 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GRK6. AA range:10-59 |
| Specificity | GRK 6 Polyclonal Antibody detects endogenous levels of GRK 6 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kD |
| Background | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors.,PTM:It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Widely expressed., |
| Subcellular location | Membrane; Lipid-anchor. |
| Expression | Widely expressed. |
Additional Images
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Western Blot analysis of Jurkat cells using GRK 6 Polyclonal Antibody
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Immunofluorescence analysis of HeLa cells, using GRK6 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from Jurkat, COLO205, and HUVEC cells, using GRK6 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES5624-100
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