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Antibody Product Overview
| ELK.No | ES5640 |
| Product name | GluR-δ2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | GRID2; GLURD2; Glutamate receptor delta-2 subunit; GluR delta-2 subunit |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2895 |
| Human Swiss-Prot | O43424 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GRID2 |
| Fields | >>Neuroactive ligand-receptor interaction;>>Long-term depression |
| Gene name | GRID2 |
| Protein name | Glutamate receptor delta-2 subunit |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14804 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61625 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 79220 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63226 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880 |
| Specificity | GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 113kD |
| Background | The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this |
| Function | domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . |
| Expression | Brain,Cerebellum,PCR rescued clones, |
Additional Images
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Western Blot analysis of 3T3 cells using GluR-δ2 Polyclonal Antibody
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Immunofluorescence analysis of HUVEC cells, using GRID2 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from mouse brain, using GRID2 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES5640-50
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