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Glycogen Synthase 1 (phospho Ser645) rabbit pAb
AO-06-ES5702-100
Antibody Product Overview
| ELK.No | ES5702 |
| Product name | Glycogen Synthase 1 (phospho Ser645) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | GYS1; GYS; Glycogen [starch] synthase; muscle |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2997 |
| Human Swiss-Prot | P13807 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Glycogen Synthase 1 |
| Fields | >>Starch and sucrose metabolism;>>Metabolic pathways;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Insulin signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>Diabetic cardiomyopathy |
| Gene name | GYS1 |
| Protein name | Glycogen [starch] synthase muscle |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14936 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9Z1E4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 690987 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | A2RRU1 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Glycogen Synthase around the phosphorylation site of Ser645. AA range:611-660 |
| Specificity | Phospho-Glycogen Synthase 1 (S645) Polyclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein only when phosphorylated at S645. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 83kD |
| Background | The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009], |
| Function | catalytic activity:UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).,disease:Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also called muscle glycogen synthase deficiency. GSD0 is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.,enzyme regulation:Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does.,function:Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.,pathway:Glycan biosynthesis; glycogen biosynthesis.,similar |
| Subcellular location | cytosol,membrane,inclusion body, |
| Expression | Endometrium,Heart,Kidney,Lymph,Muscle,Skin, |
Additional Images
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Western Blot analysis of 293 cells using Phospho-Glycogen Synthase 1 (S645) Polyclonal Antibody
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Glycogen Synthase (Phospho-Ser645) Antibody
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Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using Glycogen Synthase (Phospho-Ser645) Antibody. The picture on the right is blocked with the phospho peptide.
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Western blot analysis of lysates from NIH/3T3 cells treated with PMA 125ng/ml 30', using Glycogen Synthase (Phospho-Ser645) Antibody. The lane on the right is blocked with the phospho peptide.
: AO-06-ES5702-100
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