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Antibody Product Overview
| ELK.No | ES5725 |
| Product name | Orexin R-1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | HCRTR1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1R; Hypocretin receptor type 1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3061 |
| Human Swiss-Prot | O43613 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Orexin R-1 |
| Fields | >>Neuroactive ligand-receptor interaction |
| Gene name | HCRTR1 |
| Protein name | Orexin receptor type 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 230777 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P58307 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25593 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P56718 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HCRTR1. AA range:231-280 |
| Specificity | Orexin R-1 Polyclonal Antibody detects endogenous levels of Orexin R-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 50kD |
| Background | The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009], |
| Function | function:Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . |
| Expression | Brain, |
Additional Images
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Western blot analysis of lysates from RAW264.7 cells, using HCRTR1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HepG2 cells using HCRTR1 antibody.
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: AO-06-ES5725-50
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