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Antibody Product Overview
| ELK.No | ES5735 |
| Product name | KChIP1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | KCNIP1; KCHIP1; VABP; Kv channel-interacting protein 1; KChIP1; A-type potassium channel modulatory protein 1; Potassium channel-interacting protein 1; Vesicle APC-binding protein |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 30820 |
| Human Swiss-Prot | Q9NZI2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | KChIP1 |
| Fields | |
| Gene name | KCNIP1 |
| Protein name | Kv channel-interacting protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 70357 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9JJ57 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 65023 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q8R426 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KCIP1. AA range:1-50 |
| Specificity | KChIP1 Polyclonal Antibody detects endogenous levels of KChIP1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 27kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013], |
| Function | function:Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,subunit:Component of heteromultimeric potassium channels. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Can self-associate to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. Interacts with Naja atra venom CTX3.,tissue specificity:Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform |
| Subcellular location | Cell membrane ; Peripheral membrane protein . Cytoplasm . Cell projection, dendrite . |
| Expression | Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus. |
Additional Images
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Immunofluorescence analysis of HeLa cells, using KCIP1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KCIP1 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES5735-50
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