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Histamine H2 Receptor rabbit pAb
AO-06-ES5777-50
Antibody Product Overview
| ELK.No | ES5777 |
| Product name | Histamine H2 Receptor rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IF;ELISA |
| Other name | HRH2; Histamine H2 receptor; H2R; HH2R; Gastric receptor I |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3274 |
| Human Swiss-Prot | P25021 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Histamine H2 Receptor |
| Fields | >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gastric acid secretion |
| Gene name | HRH2 |
| Protein name | Histamine H2 receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P97292 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HRH2. AA range:131-180 |
| Specificity | Histamine H2 Receptor Polyclonal Antibody detects endogenous levels of Histamine H2 Receptor protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 40kD |
| Background | Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008], |
| Function | function:The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway.,miscellaneous:Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease.,online information:H2 receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Brain,Liver,Skin,Stomach, |
Additional Images
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Western Blot analysis of 3T3 cells using Histamine H2 Receptor Polyclonal Antibody
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Immunofluorescence analysis of LOVO cells, using HRH2 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES5777-50
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