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Antibody Product Overview
| ELK.No | ES5800 |
| Product name | SR-2A rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | IHC;IF;ELISA |
| Other name | HTR2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3356 |
| Human Swiss-Prot | P28223 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SR-2A |
| Fields | >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Serotonergic synapse;>>Inflammatory mediator regulation of TRP channels |
| Gene name | HTR2A |
| Protein name | 5-hydroxytryptamine receptor 2A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P35363 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human 5-HT-2A. AA range:422-471 |
| Specificity | SR-2A Polyclonal Antibody detects endogenous levels of SR-2A protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 53kD |
| Observed band (KD) | |
| Background | This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009], |
| Function | domain:The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localizes to the post-synaptic thickening of axo-dendritic synapses.,subunit:Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cytoplasmic vesicle . Membrane, caveola . Cell junction, synapse, presynapse . |
| Expression | Detected in brain cortex (at protein level). Detected in blood platelets. |
Additional Images
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Immunofluorescence analysis of A549 cells, using 5-HT-2A Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-2A Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES5800-100
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